An in-vitro gastric simulator capable of mimicking stomach motility with real food inputs.
GDS is a simulator that replicates the human stomach under physiologically relevant conditions.
It generates peristaltic motion and allows the introduction of real food to recreate fed-state gastric environments.
GDS is suitable for comparing fed and fasted conditions in pharmaceutical formulation development.
“What if you could simulate the stomach with actual meals?”
Standard dissolution testers rely on paddle rotation, unlike the human stomach, which may reduce physiological relevance.
ICH M13A requires evaluations in both fed and fasted states.
Are you facing difficulties in conducting studies that align with these requirements?
※《参考》ICH M13A(2025年10月ガイダンス版 Eng.)
Capable of simulating gastric behavior and conditions
GDS was developed to simulate food digestion and is utilized in research on the dissolution behavior of pharmaceutical formulations.
GDS scientifically simulates gastric behavior and conditions, enabling peristaltic motion and pH environments similar to those of the human stomach.
Allowing food to be added directly into the gastric chamber enables reproduction of the fed-state stomach, and supports compliance with the ICH M13A guideline.
Studies are underway at several academic institutions, and pharmaceutical adoption is expanding. It is gaining increasing attention.
Scientifically grounded gastric behavior simulation—now with real-food testing capability.
By using simulated digestive fluids and adding artificial gastric fluids, physiological pH conditions can be reproduced. The peristaltic mechanism allows simulation of food disintegration, mixing, and flow. Peristaltic cycle and speed can be configured according to published data.
A syringe pump that can aspirate samples containing food enables programmable sampling intervals. Under low-food conditions, a peristaltic pump can be used, allowing programming based on gastric emptying rates (e.g., first-order kinetics).
The water jacket keeps the chamber at around 37 °C, replicating human body temperature. We have also developed a chamber with a downward bulge to prevent tablets or food from accumulating near the pylorus parts.
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